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. 2014 Dec 8;35(1):132–136. doi: 10.3343/alm.2015.35.1.132

Fig. 2.

Fig. 2

High-resolution single nucleotide polymorphism array (HR SNP-A) analysis results in whole chromosomes at diagnosis (idiograms of six chromosomes harboring aberrations are provided) in Case 2 (A). The array results showed heterozygous interstitial deletions of 3q13, 4q23q24, 5q15q21.3, 5q21.3q22.1, 5q22.3q23.1, 5q34, 6q16.3q21, 7q11.23, and 13q14.2q14.3, including RB1 gene. Deleted lesions are indicated separately with red arrows, and the detailed array results for each lesion are provided. Identical array results for whole chromosome at relapse in Case 2 (B) showed similar results, but slight size changes in deleted genomic lesions at 3q13, 4q23q24, 5q15q21.3, 5q21.3q22.1, 5q34, and 13q14.2q14.3 were identified at relapse compared to those at diagnosis. Deleted lesions are also indicated separately with red arrows, and detailed array results for each lesion are provided. In addition, HR SNP-A analysis results of chromosome 9 performed at both diagnosis and relapse in Case 3 (C) are provided. The deleted lesion is indicated with a red box, and detailed array result is provided. The array result showed an interstitial 451 kb deletion of 9p21.3, which includes IFNA13 and MIR31 in a mosaic pattern.