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Parameters of thrombin generation assay. Tissue factor addition generates thrombin along the reaction time, and the resulting thrombin generation curve can be drawn as the above bell-shaped curve. Lag time is the point at which one-sixth of the peak thrombin height is reached; time-to-peak is the point at which the peak thrombin height is reached. Peak thrombin is the maximum thrombin height, and endogenous thrombin potential (ETP) is the area under the thrombin generation curve.
