Fig. 3.

A time-of-day-dependent variation of locomotor activity in NC/Tnd mice. As locomotor activity, moving distance of 36 NC/Tnd mice (male, n=16; female, n=20) with moderate to severe dermatitis between 12 and 24 weeks of age were recorded for 24 hr at the same time of scratching behavior analysis. The white and black bars above the graph indicate the light and dark periods, respectively. Data represent the mean of 36 mice ± SEM. Friedman test detected significant difference of data among the different times (P<0.05).