Table 1.
Subsets of human dendritic cells
| Plasmacytoid dendritic cells | Myeloid dendritic cells | ||
| Morphology | Round, resemble plasma cells | Prominent cytoplasmic protrusions | |
| Phenotype | CD11C- CD1a+ | CD11c+ CD1a+ | |
| CD123high | CD123low | ||
| mDC1 | mDC2 | ||
| BDCA-4+ (CD304+) | |||
| BDCA-2+ (CLEC4C) | BDCA-1+ (CD1c+) | BDCA-3+ (CD141+) | |
| CLEC9A | |||
| TLR receptor expression | TLR1, TLR6, TLR7, TLR9, TLR10 | TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8,TLR10 | TLR1, TLR2, TLR3,TLR6, TLR8, TLR10 |
| MHC I | + | ++ | ++ |
| MHC II | + | +++ | ++ |
| CD86 | + | +++ | ++ |
| CD40 | + | ++ | +++ |
| CXCR3 | +++ | + | ++ |
| ICOS L | ++ | + | +++ |
mDC: Myeloid dendritic cell; BDCA: Blood dendritic cell antigen; TLR: Toll like receptor; MHC: Major histocompatibility complex; CXCR3: Chemokine receptor 3; ICOSL: Inducible costimulator ligand.