Table 1.
Gene ontology analysis of senescent hepatocyte gene expression signature
| Gene list | Ontology | % list | P value | Fold enrichment |
| A: senescence induced | Steroid metabolism | 8.5 | 5.50E-12 | 7.4 |
| Endoplasmic reticulum | 15.7 | 7.10E-9 | 2.8 | |
| Oxidation/reduction | 12.1 | 8.00E-9 | 3.5 | |
| Drug metabolism | 4.8 | 7.80E-8 | 8.6 | |
| Lysosome | 6.0 | 2.20E-6 | 4.9 | |
| Retinol metabolism | 4.0 | 2.20E-6 | 8.3 | |
| Signal peptide | 27.8 | 1.40E-5 | 1.7 | |
| Iron ion binding | 6.5 | 3.20E-5 | 3.6 | |
| Defence response | 8.5 | 3.00E-4 | 2.5 | |
| Lipid biosynthesis | 5.6 | 5.40E-4 | 3.1 | |
| Lipid catabolism | 4.0 | 7.20E-4 | 4.1 | |
| Secreted | 14.9 | 1.50E-3 | 1.7 | |
| Regulation of apoptosis | 9.3 | 1.90E-3 | 2.0 | |
| Inflammatory response | 4.4 | 1.50E-2 | 2.4 | |
| B: secreted | Disulfide bond | 62.2 | 3.90E-10 | 4.1 |
| Plasma | 16.2 | 9.10E-7 | 32.6 | |
| Glycoprotein | 56.8 | 2.10E-5 | 2.5 | |
| Defence response | 21.6 | 2.10E-4 | 6.0 | |
| Immune response | 16.2 | 1.10E-2 | 4.2 | |
| Lipid binding | 13.5 | 1.40E-2 | 5.0 | |
| Cell adhesion | 13.5 | 5.80E-2 | 3.3 | |
| Regulation of proliferation | 13.5 | 8.30E-2 | 2.9 |
Gene ontology enrichment in (A) senescence-induced genes and (B) senescence-induced genes falling in the “Secreted” ontology was analysed using DAVID.