FIG. 5.

dNSC transplant results in increased tissue sparing after SCI. (A) Representative histological images with H&E and LFB stains are shown for each group at the injury epicenter and 1,120 μm rostral and caudal to the injury epicenter. Scale bar represents 500 μm (B, C) Histological analysis of spinal cord sections from dNSC transplantation, media, and sham injured mice revealed significant differences between dNSC and growth media groups in total cord and gray matter volume across the entire cord and at several individual section points. (D) A trend but no significant differences were seen between dNSC and growth media groups in white matter volume, although significant differences were found at certain individual section points caudal to the injury epicenter. (E) No significant differences were seen between dNSC and media groups in lesion volume or at individual section points. Data represent mean±SEM, * indicates P<0.05 two-way ANOVA with LSD post-hoc for area analysis and one-way ANOVA with LSD post-hoc for volume analysis; Sham, n=3; dNSC, n=6; growth media, n=6. LFB, Luxol fast blue. Color images available online at www.liebertpub.com/scd