Table 1.
Ionic Concentration of MD Perfusates, Reference Range for CSF Ionic Concentrations and Range of In Vitro Tested Concentrations
| Ionic concentration of MD perfusates | |||||||
|---|---|---|---|---|---|---|---|
| CNS perfusion fluid | CNS perfusion fluid+3% albumin | Ringera | Ringer lactatedb | Normal saline | Control group (lower-upper) | In vitro tested concentrations | |
| Na+ (mmol/L) | 147 | 143.5 | 145.3 | 130 | 154 | 130–164 | 115–195 |
| K+ (mmol/L) | 2.7 | 2.6 | 5.4 | 5.4 | — | 2.8–3.6 | 2.0–7.5 |
| Cl− (mmol/L) | 153.8 | 144.9 | 155.3 | 111.8 | 145 | 115–144 | 120–192 |
| Ca2+(mmol/L) | 1.2 | 1.02 | 4.6 | 2.7 | — | — | — |
| Mg2+ (mmol/L) | 0.85 | 0.72 | — | — | — | — | — |
| Osmolarity (mOsm/L) | 305 | 286 | 308.6 | 273 | 308 | — | — |
Lower-upper indicates lower upper thresholds calculated by the robust method described in the National Committee on Clinical Laboratory Standards (NCCLS) and Clinical and Laboratory Standards Institute (CLSI) guidelines C28-A2 and C28-A3 (n=22).
a
Composition from Fresenius Kabi (Bad Homburg, Germany).
b
Composition from B. Braun Melsungen AG (Melsungen, Germany).
MD, microdialysis; CSF, cerebrospinal fluid.