Table 2.
Active chemical groups | Active molecules | General mode of action |
Alcohols | Ethanol Benzyl alcohol |
Inhibition of DNA and RNA synthesis |
Aldehydes | Glutaraldehyde Formaldehyde |
Alkylating agents |
Amphiphiles |
Didecyldimethyammonium chloride Benzalkonium chloride |
Membrane destabilizer, cytoplasmic protein aggregation |
Azole derivatives |
Enilconazole Miconazole Tebuconazole |
Inhibition of the ergosterol synthesis, interaction with DNA |
Biguanides | Chlorhexidine | Inhibition of membrane-bound adenosine triphosphatase (ATPase) |
Carbamates |
Bendiocarb Carbendazim Carbofuran |
Inactivation of the acetylcholinesterase |
Halogens | Chlorine Iodine |
Oxidizing agents |
Heavy-metal derivates |
Copper Silver |
Interaction with thiol residues |
Neonicotinoids |
Imidacloprid Sulfoxaflor |
Binding to nicotinic acetylcholine receptors |
Organic acids | Lactic acid p-Hydroxybenzoic acid ester Butylparaben |
Dissipation of proton motive force and inhibition of uptake amino acids |
Organophosphates |
Chloramidophos DCPE |
Inactivation of the acetylcholinesterase |
Phenol, Bisphenol and derivatives |
m-Cresol Pentachlorophenol Triclosan |
Inhibition of uptake amino acids, modification of membrane potential |
Pyrethroids | Allethrin Cypermethrin |
Modification of membrane potential |
Quinolones |
Ciprofloxacin Levofloxacin |
Inhibition of the topoisomerase |
Terpenes | Limonene trans-cinnamaldehyde Eugenol |
Unknown membrane interaction |
aNote that the list is not exhaustive. The reader can consult reference [15] for more details.