Skip to main content
. 2014 Dec 1;5:2293–2307. doi: 10.3762/bjnano.5.238

Figure 5.

Figure 5

Anticancer efficacy of a supramolecular complex against PTX-resistant melanoma B16F10 cells. (a) Survival of B16F10 melanoma cells treated with paclitaxel or the DDMC–paclitaxel complex for 48 h determined by using the MTT (WST8) method (blue solid line: DDMC/PTX, purple dashed line: DDMC, orange dashed line: PTX). (b) Tubulin polymerization and cell death (Cd) rates can be expressed by enzymatic kinetic parameters. Relationship between Cd and paclitaxel concentration, [E]0, after 24 h and 48 h. After 24 h: Cd = 0.1062 [E]0 + 0.0481; after 48 h: Cd = 0.1156 [E]0 + 0.1082. (c) Apparatus constant (C1) by cell culture time in WST8 vs time (h) for DDMC/PTX complex. Reprinted from [24].