Table 3.
Stool fatty acid soaps (mg/g dry weight stool) at day 28
| Primary fatty acid soap endpoints 1 | Feeding group | Statistically significant group differences 2 | |||
|---|---|---|---|---|---|
| Control | sn -2 | sn -2+OF | HM | ||
| (n =46) | (n =51) | (n =49) | (n =48) | ||
| C16:0 FA soap (palmitate) | 186.9 ± 48.8 | 159.3 ± 42.0 a | 113.3 ± 43.1b, c | 26.0 ± 26.2d | a P =0.0028 vs. control |
| b P <0.0001 vs. control | |||||
| Total FA soaps | 272.8 ± 67.9 | 251.4 ± 65.1 | 175.6 ± 64.1b, c | 63.5 ± 56.3d | c P <0.0001 vs. sn-2 |
| d P <0.0001 vs. all formulas | |||||
| Secondary endpoints - individual FA soaps1, 3 | |||||
| C12:0 FA soap (lauric) | 4.6 ± 2.0 | 3.2 ± 1.4 | 1.6 ± 1.4 | 0.3 ± 0.4 | |
| C14:0 FA soap (myristic) | 13.7 ± 4.5 | 9.6 ± 3.0 | 6.0 ± 3.2 | 1.3 ± 1.5 | |
| C18:0 FA soap (stearic) | 37.8 ± 8.7 | 38.6 ± 9.8 | 31.4 ± 10.5 | 23.2 ± 20.5 | |
| C18:1 FA soap (oleic) | 20.0 ± 8.7 | 29.3 ± 9.9 | 15.5 ± 10.5 | 8.4 ± 8.8 | |
| C18:2 FA soap (linoleic) | 3.2 ± 1.6 | 3.4 ± 1.4 | 1.8 ± 1.7 | 1.6 ± 1.6 | |
1Mean ± SD.
2Based on analysis of variance followed by pairwise comparisons for formula groups, and independent t-tests for each of the formula groups vs. HM group.
3Descriptively summarized; no statistical analysis done.
Control = bovine milk-based, whey-predominant, alpha-lactalbumin-enriched term infant formula with 100% vegetable fat blend; FA = fatty acid; HM = human milk; sn-2 = high sn-2 palmitate formula (Control formula modified to contain 60% vegetable fat blend and 40% high sn-2 palmitate fat blend); sn-2+OF = high sn-2 palmitate formula supplemented with oligofructose at 3.0 g/L.
Statistical significance: a: P =0.0028 vs. control, b: P <0.0001 vs. control, c: P <0.0001 vs. sn-2 and d: P <0.0001 vs. all formulas.