Fig. 3.
Electrophysiological characterization of hiPSC-CMs. A–D show results for the wt1-, carrier478-2A/T-, and JLNS478-2T/T-CMs, and E–H for the wt2-, LQT11781G/A-, and JLNS1781A/A-CMs. (A and E) FPD quantification on MEAs. (B and F) Representative APs at 1 Hz. (C and G) Average APD20, APD50, APD90, dV/dtmax, RMP, APA, and PlaA. (D and H) Frequency dependence of APD90 (Left). Most JLNS-CMs could not be paced at high frequencies (Right). Symbols *, &, and # indicate statistical significance based on pairwise comparisons (P < 0.05).