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. 2014 Dec 2;111(50):E5401–E5410. doi: 10.1073/pnas.1407792111

Fig. 1.

Fig. 1.

Genetic events in leukemic transformation of chronic-phase MPNs. (A) Frequency of mutations in post-MPN AML samples (n = 33). Hash marks indicate structural rearrangements (for scale reference, alterations were observed at a frequency of 3.1% beginning with ARID1A and extending to ZRSR2 in this representation). (B) Circos representation of co-occurring mutations in JAK2-mutant post-MPN AML. (C) Circos representation of co-occurring mutations in JAK2-wildtype post-MPN AML. (D) VAF of the most frequently mutated genes in post-MPN AML, in paired chronic-phase MPN and AML. (E) Representative analysis of VAF of mutations and bone marrow blasts occurring at chronic MPN phase and AML stage from a single patient.