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. 2014 Dec 2;111(50):E5401–E5410. doi: 10.1073/pnas.1407792111

Fig. 4.

Fig. 4.

Loss of Tp53 in the JAK2V617F setting confers increased self-renewal to committed progenitor populations. (A) Methylcellulose replating assay demonstrating enhanced self-renewal of Tp53-KO/JAK2V617F whole bone marrow. (B) Serial transplantation of whole spleen cells derived from leukemic Tp53-KO/JAK2V617F mice demonstrates significantly reduced latency with serial transplantation (P < 0.05 primary versus secondary, P < 0.05 secondary versus tertiary, log-rank test). (C) Transplantation of spleen cells from Tp53-KO/JAK2V617F leukemic mice results in the development of leukemia in both lethally and sublethally irradiated recipient mice. (D) Transplantation of the MEP population from Tp53-KO/JAK2V617F mice with leukemic phenotype into lethally irradiated recipients results in the development of leukemia in mice surviving longer than 20 d (n = 7).