Table 1.
The 84 MAPK pathway-linked genes considered in our analyses
| Gene | Gene | Gene | |||
|---|---|---|---|---|---|
| 01 | ATF2 | 38 | MAP3K5 | 73 | TRADD |
| 02 | CREB1 | 39 | MAP3K6 | 74 | TGFB1 |
| 03 | CEBPA | 40 | MAP3K7 | 75 | TGFB2 |
| 04 | CHUK | 41 | MAP3K8 | 76 | TGFB3 |
| 05 | DAXX | 42 | MAP3K9 | 77 | TGFBR1 |
| 06 | ELK1 | 43 | MAP4K1 | 78 | FOS |
| 07 | GRB2 | 44 | MAP4K2 | 79 | HRAS |
| 08 | IKBKB | 45 | MAP4K3 | 80 | MYC |
| 09 | JUN | 46 | MAP4K4 | 81 | ARAF |
| 10 | MKNK1 | 47 | MAP4K5 | 82 | BRAF |
| 11 | MKNK2 | 48 | MAPKAPK2 | 83 | RAF1 |
| 12 | MAPK1 | 49 | MAPKAPK3 | 84 | RELA |
| 13 | MAPK10 | 45 | MAP4K3 | ||
| 14 | MAPK11 | 50 | MAPKAPK5 | ||
| 15 | MAPK12 | 51 | MAX | ||
| 16 | MAPK13 | 52 | MEF2A | ||
| 17 | MAPK14 | 53 | MEF2B | ||
| 18 | MAPK3 | 54 | MEF2C | ||
| 19 | MAPK4 | 50 | MAPKAPK5 | ||
| 20 | MAPK6 | 55 | MEF2D | ||
| 21 | MAPK7 | 56 | NFKB1 | ||
| 22 | MAPK9 | 57 | NFKBIA | ||
| 23 | MAP2K1 | 58 | PAK2 | ||
| 24 | MAP2K2 | 59 | PAK1 | ||
| 25 | MAP2K3 | 60 | RAC1 | ||
| 26 | MAP2K4 | 61 | RIPK1 | ||
| 27 | MAP2K5 | 62 | RPS6KB1 | ||
| 28 | MAP2K6 | 63 | RPS6KB2 | ||
| 29 | MAP2K7 | 64 | RPS6KA1 | ||
| 30 | MAP3K10 | 65 | RPS6KA2 | ||
| 31 | MAP3K11 | 66 | RPS6KA3 | ||
| 32 | MAP3K12 | 67 | RPS6KA4 | ||
| 33 | MAP3K13 | 68 | RPS6KA5 | ||
| 34 | MAP3K14 | 69 | SHC1 | ||
| 35 | MAP3K2 | 70 | STAT1 | ||
| 36 | MAP3K3 | 71 | SP1 | ||
| 37 | MAP3K4 | 72 | TRAF2 |
To our knowledge, this is the first human study to systematically evaluate MAPK gene-promoter methylation using a wide collection of upstream and downstream pathway components with respect to ambient air pollution exposures.