Table 2.

Hypofractionated adjuvant/salvage radiotherapy

Reference	Study design	Institution	Patient collection	Fractionation(total dose/singel dose/fractions)	EQD for tumor α/β ratio 1.4Gy	EQD for normal tissue α/β ratio 3Gy	IMRT	Follow-up	Acute GU toxicitiy	Late GU toxicity	Acute GI toxicity	Late GI toxicity	Therapeutic outcomes
Cozzarini, C. [23]	Prospective phase I-II for adjuvant RT	Milan, Italy	247 patients	65.8Gy/2.35Gy/28 fractions adj. RT for 117 pat.; 71.4-72.8Gy/2.55Gy/28 fractions salvage RT for 80 pat.; 58Gy/2.9Gy/20 fractions for 50 pat. Conventional arm 929 pat. 70.2Gy/1.8Gy/39 fractions	72.6Gy adjuvant RT; 83.0Gy salvage RT; 73.4Gy for the other 50 pat.	α/β ratio = 5Gy for late GU toxicity! 69.14Gy adjuvant RT; 77.1Gy salvage RT; 65.5Gy for the other 50 pat.	Tomo-RT	68 months median	-	41/247 (16.5%) ≥ III° GU in hypofraction arm; 72/929 (7.7%) in conventional arm	-	-	-
Kruse, T.J. [26]	Retrospective for salvage RT	Madison, Wisconsin	108 patients	65Gy/2.5Gy/26 fractions	74.6Gy	71.5Gy	IMRT	32.4 months median	8 pat. (7%) II° and 1 pat. III° GU RTOG.	16 pat. (15%) II° GU RTOG.	15 pat. (14%) II GI RTOG.	4 (4%) pat. II° GI RTOG.	freedom from biochem. failure at 4 years 67% ± 5.3%.
Ippolito, E. [24]	Prospective phase I for dose-escalation, adjuvant RT	Campobasso, Italy	25 patients	7 pat. 56.8Gy/2.27Gy/25 fractions; 6 pat. 59.7Gy/2.39Gy/25fractions; 6 pat. 61.25Gy/2.45Gy/25fractions; 6 pat. 62.5Gy/2.5Gy/25 fractions	7 pat. 61.3Gy; 6 pat. 66.5Gy; 6 pat. 69.4Gy; 6 pat. 71.7Gy.	7 pat. 59.9Gy; 6 pat. 64.4Gy; 6 pat. 66.8Gy; 6 pat. 68.8Gy.	IMRT	19 months median	9/25 (36%) II° GU.	-	5/25 (20%) II° GI.	-	-
Lee, W. [52]	Retrospective for salvage RT	Manchester	37 patients	50-52.5Gy/2.5-2.63Gy/20 fractions	57.4-62.2Gy	55-59.1Gy	-	30.6 months median	0% II° GU.	16 pat. I° GU, 0 pat. II° GU.	0% II° GI.	4 pat. I° GI, 1 pat. II° GI.	3-year disease-free survival is 74%.