Table 1. Ten-year estimates of post-relapse survival (PRS) and post-relapse event-free survival (PREFS) for 110 patients with relapsed osteosarcoma according to patient and disease characteristics and treatment.

		PRS ± SE (%)		PREFS ± SE (%)
Factor	n	10-Year Estimate	P-value	10-Year Estimate	P-value
Age at Diagnosis
≤14 years	53	14.0 ± 6.5	0.8187	13.2 ± 6.2	0.6023
>14 years	57	19.3 ± 5.5		10.5 ± 3.8
Gender
Female	49	20.4 ± 7.4	0.9818	16.3 ± 6.7	0.4063
Male	61	14.6 ± 4.8		8.2 ± 3.2
Race
White	82	16.6 ± 5.0	0.8961	11.0 ± 4.2	0.9402
Black or Hispanic	28	17.9 ± 7.2		14.3 ± 5.9
Stage at diagnosis
Localized	95	17.5 ± 4.6	0.5326	11.6 ± 3.6	0.4047
Metastatic	15	13.3 ± 8.8		13.3 ± 8.8
Chemotherapy at diagnosis
2 or 3 agents	72	15.2 ± 4.7	0.118	9.1 ± 3.5	0.197
4 agents	38	20.7 ± 8.3		15.8 ± 7.2
Time to Relapse
<18 months	63	4.8 ± 2.7	<0.0001	3.2 ± 1.8	<0.0001
≥ 18 months	47	33.3 ± 8.2		23.4 ± 7.2
Site of Relapse
Lung only	82	20.7 ± 5.3	0.0842	13.4 ± 4.2	0.4996
Other sites (± lung)	28	5.4 ± 3.7		7.1 ± 4.9
Ability to Achieve a 2nd CR
Achieved CR2	62	30.2 ± 7.0	<0.0001	21.0 ± 5.9	<0.0001
Did not achieve CR2	48	0 ± 0		0 ± 0
Treatment at First Relapse
Surgery at First Relapse
No	26	0 ± 0	<0.0001	0 ± 0	0.0002
Yes	84	22.3 ± 5.4		15.5 ± 4.5
Chemotherapy at First Relapse
No	60	26.7 ± 6.9	0.0004	18.3 ± 5.5	0.0111
Yes	50	5.3 ± 3.0		4.0 ± 2.8
Radiation at First Relapse
No	107	17.5 ± 4.4	0.6486	12.1 ± 3.6	0.6125
Yes	3	0 ± 0		0 ± 0
Treatment at any Relapse
Chemotherapy at any Relapse
No	30	46.7 ± 10.8	0.0001	36.7 ± 9.7	<0.0001
Yes	80	5.5 ± 2.7		2.5 ± 1.7
Radiation at any Relapse
No	89	21.0 ± 5.2	0.506	14.6 ± 4.3	0.2326
Yes	21	0 ± 0		0 ± 0