Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec 22;8:407. doi: 10.3389/fncel.2014.00407

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Jurado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The presynaptic SNARE complex. Drawing of the SNARE fusion machinery mediating calcium-dependent exocytosis of synaptic vesicles. The cartoon illustrates the functional elements of the presynaptic SNARE complex: syntaxin-1 (Stx-1) in an open conformation via interaction with the SM protein Munc-18, SNAP-25 and synaptobrevin-2 (Syb-2). The calcium sensor synaptotagmin-1 (Syt-1) with two calcium-binding C2 domains is located at the vesicle membrane. Upon calcium entry, Syt-1 interacts with complexin (not shown) to promote neurotransmitter release.