Table 5.
Mortality end points in included studies and results for EPN, LPN and EN groups
| Outcome | Study |
Study arms |
Significance of results | ||
|---|---|---|---|---|---|
| EPN | LPN | EN | |||
| Mortality in ICU (%) |
Casaer 2011[13] |
6.3 |
6.1 |
x |
p = 0.76 |
| Heidegger 2013 [15] |
x |
0.5 |
7.0 |
p = 0.2118 |
|
| Mortality in hospital (%) |
Casaer 2011[13] |
10.9 |
10.4 |
x |
p = 0.63 |
| Mortality at discharge (%) |
Casaer 2011[13] |
28.3 |
24.8 |
x |
p = 0.007 (discharge from ICU) |
| Kutsogiannis 2011 [16] |
NR |
NR |
NR |
EPN vs EN: HR 0.75; 95% CI 0.59 to 0.96; LPN vs EN: HR 0.64, 95% CI 0.51 to 0.81 (discharge from hospital) |
|
| Mortality at day 28 (%) |
Heidegger 2013 [15] |
x |
13.0 |
18.0 |
p = 0.1193 |
| Mortality at day 60 (%) |
Cahill 2011 [12] |
42.2 |
27.9 |
34.2 |
p = 0.17 |
| Kutsogiannis 2011 [16] |
34.6 |
35.3 |
27.8 |
p = 0.02† |
|
| Mortality at day 90 (%) |
Bauer 2000 [11] |
28.0 |
x |
30.0 |
no p-value, ns |
| Casaer 2011[13] |
11.2 |
11.2 |
x |
p = 1.00 |
|
| Mortality at 2 years (%) | Bauer 2000 [11] | 40.0 | x | 40.0 | no p-value, ns |
EPN, early parenteral nutrition; LPN, late parenteral nutrition; EN, enteral nutrition; ICU, intensive care unit; x, not applicable; p, p-value; ns, nonsignificant; NR, not reported; vs, versus; HR, hazard ratio; 95% CI, 95% confidence interval. NB: studies used different definitions for EPN, LPN and EN. †, comparing EN versus LPN.