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Dual effect of a cyclic (c)GMP analogue, 8-bromo-cGMP (8-B-cGMP) (25 μg to 1000 μg), on nociceptive thresholds in rat paws. Low doses of the cGMP analogue (25 μg) induced analgesia and higher doses induced hyperalgesia. *Significantly different from vehicle (P<0.01); n=4 animals per group. AUC Area under the curve; Veh Vehicle
