Figure 5).

Reversal of the analgesic effect induced by Y27632 (Y) (25 μg or 500 μg) by cytochalasin B (CB) (1 μg) in rat paws. CB was injected 5 min before administration of a low (25 μg) or a high (500 μg) dose of Y locally. CB and Y were diluted in a solution of dimethyl sulfoxide and isotonic saline (vehicle [Veh]). ^#Significant difference between Veh-Y500 and CB-Y500 (P<0.05). n=3 to n=5 animals per group