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. 2014 Aug 1;4:25. doi: 10.1186/s13613-014-0025-9

Table 3.

Time-course of hemodynamic variables according to fluid responsiveness status

Variable T0 (baseline) T1 (30 min) T2 (60 min) T3 (90 min)
CI (L/min/m2)
 R
 2.84 ± 0.61
 3.57 ± 0.65*
 3.19 ± 0.69*,+
 3.06 ± 0.70+
NR
 3.40 ± 0.55
 3.59 ± 0.74
 3.31 ± 0.61
 3.24 ± 0.55
RAP (mmHg)
 R
 8.54 ± 3.36
 10.23 ± 3.72*
 9.08 ± 3.59*,+
 9.23 ± 3.54*,+
NR
 7.57 ± 2.37
 9.71 ± 1.98*
 8.86 ± 1.95*,+
 8.86 ± 2.27*,+
PAOP (mmHg)
 R
 8.77 ± 3.30
 10.64 ± 4.03*
 8.69 ± 3.2
 8.89 ± 3.62
NR
 8.04 ± 3.08
 9.17 ± 3.06*
 9.01 ± 3.30
 8.26 ± 3.05
MAP (mmHg)
 R
 74.62 ± 6.84
 83.92 ± 8.20*
 79.62 ± 10.94
 79.77 ± 14.02
NR
 72.00 ± 10.63
 77.57 ± 11.36*
 74.86 ± 8.84
 73.57 ± 10.83
HR (beats/min)
 R
 107.54 ± 19.83
 105.77 ± 19.63
 107.85 ± 20.43
 108.62 ± 21.06
NR
 111.71 ± 16.80
 106.86 ± 16.31
 106.43 ± 18.17
 105.57 ± 17.42
Lactate (mmol/L)
 R
 2.78 (1.50 to 6.89)
 2.78 (1.56 to 6.72)
  
  
NR
 3.44 (2.22 to 4.22)
 3.44 (2.22 to 5.11)
  
  
Hb (g/dL)
 R
 9.36 ± 1.76
 9.34 ± 2.06
  
  
NR
 10.01 ± 1.36
 8.83 ± 1.26*
  
  
SvO2 (%) R
 63.00 ± 9.08
 66.30 ± 8.30*
  
  
NR 72.46 ± 5.02 74.20 ± 4.01    

R, responders; NR, non-responders; CI, cardiac index; RAP, right atrial pressure; PAOP, pulmonary artery occlusion pressure; MAP, mean arterial pressure; HR, heart rate; SvO2, mixed venous oxygen saturation; Hb, hemoglobin. The groups (R and NR) showed significant CI difference over time (p = 0.009). The CI did not change over time in NR (p = 0,306). The groups (R and NR) showed no significant difference over time in RAP, PAOP, MAP, and HR (p > 0.05). Mean values of RAP, PAOP, MAP, and HR were similar between R and NR at T0, T1, T2, and T3 (p > 0.05). The groups (R and NR) showed significant difference in SvO2 (p = 0.02) at T0. The groups (R and NR) showed no significant difference in lactate levels (p = 0.72) and Hb (p = 0.46) at T0. *p < 0.05 versus baseline, +p < 0.05 versus T1. Data are expressed as means (SD) or medians (IQR 25th to 75th percentile).