Table 1.

The various parameters for Triptans marketed in Japan[11-20]

Drugs	Administration route (dosage form)	Standard dose in Japan (mg)	MW (g/mol)	Plasma unbound fraction; fu	Ki 1B * (nM)	Ki 1D * (nM)
Sumatriptan [11-13]	SC	3	295.41	0.66	12.6	12.6
	PO	50
	NS	20
Zolmitriptan [14-16]	PO	2.5	[unchanged drug]	[unchanged drug]	[unchanged drug]	[unchanged drug]
	ODT		287.30	0.8	6.31	2.51
			[active metabolite]	[active metabolite]	[active metabolite]	[active metabolite]
			273.36	0.75	1.58	0.5
Eletriptan [17]	PO	20	382.52	0.13	10.0	1.2
Rizatriptan [18,19]	PO	10	269.35	0.86	138	13.1
	ODT
Naratriptan [20]	PO	2.5	335.47	0.71	2.2	2.3

*calculated from pKi or pIC_50.

SC: subcutaneous injection.

PO: oral tablet.

NS: nasal spray.

ODT: orally disintegrating tablet.

Ki_1B: 5-HT_1B receptor dissociation constant.

Ki_1D: 5-HT_1D receptor dissociation constant.