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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: Transplantation. 2015 Jan 15;99(1):21–28. doi: 10.1097/TP.0000000000000545

Figure 1.

Figure 1

Cell fate map of alloantigen-specific B cells during graft recognition. Early alloantigen-dependent activation of B cells and subsequent cognate interactions with T follicular helper cells at the T-B interface results into the differentiation of B cells into indicated cell fates. Within the GC, representation of alloantigen by B cells results in renewed cognate interactions with Tfh cells that shapes the post-GC B cell repertoire and causes differentiation into the indicated cell fates. Quiescent memory B cells revisit these differentiation trajectories upon alloantigen reencounter.