Table 1. Clinical and biochemical characteristics of studied patients before and after NLCD.
| CHC pts (n = 30) | NAFLD/NASH pts (n = 30) | |||||
| Variable | T0 | T30 | p-value | T0 | T30 | p-value |
| Sex (F/M) | 13/17 | 12/18 | ||||
| Age (years) | 57.7±12.3 | 57.5±12.1 | ||||
| Body weight (kg) | 73.6±10.1 | 71.2±9.7 | NS | 82.2±21.5 | 80.8±22.8 | NS |
| BMI (kg/m2) (≤25) | 26.3±4.1 | 25.8±3.7 | NS | 29.7±6.1 | 28.8±6.5 | NS |
| Systolic blood pressure (<130 mmHg) | 137.1±17.3 | 129.5±12.6 | <0.05 | 136.7±6.4 | 129.8±12.4 | <0.05 |
| Diastolic blood pressure (<80 mmHg) | 83.3±11.3 | 76.5±8.9 | <0.05 | 80.3±11.0 | 75.9±8.9 | <0.05 |
| HOMA-IR (<2) | 3.0±2.0 | 2.8±1.2 | NS | 3.1±1.9 | 3.0±1.9 | NS |
| Total cholesterol (81.1–235.5 mg/dL) | 156.3±26.0 | 141.0±21.0 | NS | 178.2±45.5 | 174.0±41.0 | NS |
| HDL cholesterol (34.7–56 mg/dL) | 54.1±15.2 | 54.1±13.1 | NS | 52.5±14.5 | 52.9±21.9 | NS |
| LDL cholesterol (54.8–120 mg/dL) | 91.5±32.1 | 80.1±45.4 | <0.001 | 109.4±40.2 | 94.5±41.5 | <0.01 |
| Triglycerides (45.1–235 mg/dL) | 112.6±22.1 | 107.1±52.8 | NS | 116.4±44.3 | 115.2±48.2 | NS |
| ALT (10–45 UI/mL) | 60.2±37.3 | 35.5±13.7 | <0.05 | 53.9±42.9 | 53.5±43.3 | NS |
| AST (9–40 UI/mL) | 75.1±59.4 | 66.8±49.4 | <0.05 | 41.5±32.5 | 37.7±31.2 | NS |
| GGT (8–61 UI/mL) | 44.6±33.8 | 42.1±29.4 | <0.05 | 50.1±49.8 | 36.0±22.9 | <0.05 |
| AP (40–129 UI/mL) | 92.1±20.2 | 65.3±13.6 | <0.05 | 76.5±36.5 | 69.2±31.1 | NS |
| hsCRP (0.1–0.6 g/L) | 0.9±0.1 | 0.4±0.1 | <0.05 | 0.6±0.1 | 0.4±0.1 | NS |
| Bilirubin (<1.20 mg/dL) | 0.53±0.1 | 0.49±0.1 | NS | 0.62±0.3 | 0.60±0.3 | NS |
| Uric acid (<7.2 mg/dL) | 5.1±1.3 | 4.5±1.2 | <0.05 | 5.0±1.3 | 4.6±1.3 | <0.05 |
| HCV RNA (log IU/mL) | 1.9± 0.2 | 1.7± 0.9 | NS | |||
| Fibroscan (0–36 kPa) | 9.1±0.5 | 6.9±0.8 | NS | 10.1±0.5 | 7.0±0.9 | NS |
| F0 (0 kPa) | 49.3% | F0: 57.3% | ||||
| F1 (0–8.5 kPa) | 35.1% | F1: 38.6% | ||||
| F2–3 (8.6–13 kPa) | 15.6% | F2: 4.1% | ||||
| HCV genotype | 1a 37%, 1b 24%, 2a/2c 39% | |||||
T0 = Before NLCD; T30 = After NLCD; Pts = Patients; F = Females; M = Males; BMI = Body max index; HOMA-IR = Homeostatic model assessment-insulin resistance; HDL = High-density lipoprotein; LDL = Low density lipoprotein; ALT = Alanine transaminase; AST = Aspartate transaminase; GGT = Gamma-glutamyl transferase; AP = Alkaline phosphatase; hsCRP = high-sensitivity C-reactive Protein. Statistical significance was accepted at p<0.05; NS = Not significant. Values are presented as mean± SD.