TABLE 1.
Summary of basic characteristics of studies included in the meta-analysis
| First Author (Year) | Race | Study Groupsa | Na | Sexa (M/F) | Agea | PNPLA3 Genotypea | MAF | OR (95% CI) | Newcastle-Ottawa Scale Score | ||||
| CC | GC | GG | G versus C | GC versus CC | GG versus CC | ||||||||
| Dutta (2013) | North Indian | Alcoholic cirrhosis Versus healthy control | 60 versus 100 | NA | 49.5 (10.3) versus 32.9 (9.5) | 24 versus 62 | 21 versus 69 | 15 versus 9 | G: 42.5%g | 2.41 (1.48, 3.92) | 1.87 (0.90, 3.89) | 4.31 (1.66, 11.15) | 8 |
| Nischalke (2011) | Caucasian | Alcoholic or HCV cirrhosis versus healthy control | 322 versus 190 | 230/92 versus 106/84 | 56 (37–82) versus 40.5 (20–86)c | 134 versus 112 | 142 versus 69 | 46 versus 9 | G: 36.3%g | 1.92 (1.44, 2.56) | 1.72 (1.17, 2.52) | 4.27 (2.00, 9.11) | 7 |
| Falleti (2011) | Caucasian | Cirrhosis versus healthy control | 483 versus 428 | 344/139 versus 314/114 | 57 (22–86) versus 49 (18–77)c | 168 versus 218 | 220 versus 175 | 95 versus 35 | G: 42.4%g | 1.84 (1.51, 2.24) | 1.63 (1.23, 2.16) | 3.52 (2.28, 5.44) | 7 |
| Trépo (2011) | Caucasian | ALD with cirrhosis versus healthy control | 265 versus 328 | NA | NA | 100 versus 181 | 130 versus 118 | 35 versus 29 | G: 37.7%g | 1.65 (1.29, 2.12) | 1.99 (1.41, 2.83) | 2.18 (1.26, 3.78) | 7 |
| Stickel (2011) | Caucasian | Alcoholic cirrhosis versus alcoholic control | 210 versus 439 | 167/43 versus 439/0 | 50 (43–55) versus 39 (34–45)d | 90 versus 264 | 93 versus 153 | 27 versus 22 | G: 35.0%g | 1.86 (1.44, 2.40) | 1.78 (1.25, 2.53) | 3.60 (1.95, 6.64) | 8 |
| Krawczyk (2011) | NA | CLD cirrhosisfversus CLD control | 201 versus 698 | 547/352 | 50 (17–83)c | 91 versus 394 | 90 versus 261 | 20 versus 43 | G: 32.3%g | 1.45 (1.14, 1.84) | 1.49 (1.07, 2.08) | 2.01 (1.13, 3.59) | 8 |
| Tian (2010) | Mestizo Mexicansb | Alcoholic cirrhosis versus alcoholic control | 482 versus 305 | 411/71 versus 257/48 | 52 (11.6) versus 39 (12.7)e | 59 versus 83 | 264 versus 198 | 371 versus 111 | C: 27.5%g | 2.28 (1.90, 2.74) | 1.88 (1.28, 2.75) | 4.70 (3.17, 6.98) | 8 |
ALD, alcoholic liver disease; CI, confidence interval; CLD, chronic liver disease; F, female; HCV, hepatitis C virus; M, male; MAF, minor allele frequency; NA, not available.
a
Data presented as cirrhosis group versus control group.
b
Mixed European and Native American ancestry.
c
Median (range).
d
Median [25th percentile and 75th percentile (Q1–Q3)].
e
Mean (standard deviation).
f
CLD patients with cirrhosis were defined by liver stiffness values ≥13.0 kPa.
g
Indicates that the allele frequencies were in Hardy-Weinberg equilibrium (Fisher’s exact test).