Fig. 2.

FMO3 knockdown in LDLRKO mice leads to decreased atherosclerotic lesion development. A: Atherosclerotic lesion size at the aortic root region of mice treated with saline, control ASO, or FMO3 ASO and fed the Western diet are shown. N = 11 for each group. Symbols are the same as Fig. 1. B: Macrophage content in the atherosclerotic lesions of the aortic root region was determined by immunohistochemistry using antibodies against CD68. Four mice from each group with three lesion sections per mouse were used in the comparison.