TABLE 1.
Plasma lipid, lipoprotein, glucose, and insulin levels of female LDLRKO mice maintained on a Western diet with various treatments
| Treatment | n | TGs | TC | HDL Cholesterol | VLDL/IDL/LDL Cholesterol | Unesterified Cholesterol | Free Fatty Acids | Glucose | Insulin |
| Saline | 12 | 301 (29) | 1,302 (74) | 79 (3) | 1,223 (72) | 415 (23) | 38 (2) | 307 (21) | 307 (43) |
| Control ASO | 12 | 429 (34)a | 1,282 (46) | 91 (3)a | 1,191 (45) | 404 (14) | 42 (3) | 350 (13) | 353 (40) |
| FMO3 ASO | 12 | 66 (5)a,b | 332 (23)a,b | 43 (3)a,b | 289 (21)a,b | 102 (7)a,b | 24 (1)a,b | 267 (12)b | 146 (25)a,b |
Mice were fasted for 4 h. Values shown are means (standard errors) of the groups. Units are mg/dl except insulin, for which the unit is pg/ml. ANOVA was also performed to analyze the differences between the three group means with all traits exhibiting P values <0.05.
a
Student’s t-test: P < 0.05 versus saline.
b
Student’s t-test: P < 0.05 versus control ASO.