Figure 5. Pancreatic immunohistochemistry, effects of an 8-week treadmill exercise regimen in studied rats.

(A) Insulin distribution and (B) pancreatic islet size. Light micrographs reveal the staining patterns of the pancreatic islets; the pancreatic islet areas (mm²) were evaluated in 209 islets. C, control sedentary group; CK sedentary rats that received K252a as in MITK and HITK groups; MIT, medium-intensity training rats; MITK, as MIT with a TrkB inhibitor (K252a) injection; HIT, high-intensity training rats; HITK, as HIT with a TrkB inhibitor injection; data are shown as means ± S.E. *p<0.05 vs. C; ^§ p<0.05 vs. HITK; ANOVA and Tukey' tests.