Table 1.

Available forms of nitrogen-containing bisphosphonates

Drug	Oral dosing			Intravenous	Hydroxyapatite binding affinity ranking	FPPS potency ranking
	Daily	Weekly	Monthly
Ibandronate	2.5 mg	20 mg	150 mg	3 mg every 3 months	Third	Third
Risedronate	5 mg	35 mg	150 mg		Fourth	Second
Alendronate	5 and 10 mg	35 and 70 mg			Second	Fourth
Zoledronic acid				5 mg annually	First	First

Abbreviation: FPPS, farnesyl pyrophosphate synthase.