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Visualizing a pathway for allostery transmission within the HNF-4α homodimer-DNA complex. Shown is the crystal structure with the domain-domain junctions inside the red-circle [16]. Signals in the LBD, including post-translational modifications such as phosphorylation and methylation, as well as disease-linked mutations in the LBDs, can all be allosterically transmitted across the quaternary structure to weaken DNA binding [16].
