TABLE 1.
Kinetics of expansion of transgenic T cells in DO11.10 × BALB/c chimeric mice during induction of oral tolerance
| Day after oral OVA | % of CD4+ KJ1-26+ cells ina:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| PP
|
MLN
|
Spleens
|
PLN
|
|||||
| Unfed mice | Fed mice | Unfed mice | Fed mice | Unfed mice | Fed mice | Unfed mice | Fed mice | |
| 1 | 2.3 | 6.0 | 3.7 | 4.6 | 3.8 | 3.3 | 4.9 | 4.4 |
| 2 | 2.6 | 11.3 | 4.4 | 4.4 | 3.9 | 2.7 | 5.6 | 3.0 |
| 4 | 2.0 | 4.7 | 4.1 | 8.8 | 3.8 | 5.0 | 5.5 | 4.3 |
| 7b | 2.1 | 3.2 | 3.3 | 5.5 | 4.2 | 5.3 | 4.0 | 4.1 |
| 11 | 2.0 | 2.2 | 4.1 | 4.3 | 9.9 | 7.0 | 36.3 | 22.0 |
| 14 | 1.1 | 1.3 | 2.3 | 3.2 | 3.4 | 3.7 | 9.8 | 6.1 |
a
Data are representative of tissues from two or three mice per group and of three independent experiments. Cell yields for each tissue were within 10% of each other in the fed and unfed groups. Boldface indicates T-cell expansion.
b
Mice were immunized with 10 μg of OVA in CFA on day 7.