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. Author manuscript; available in PMC: 2014 Dec 22.
Published in final edited form as: Curr Opin Immunol. 2014 Oct 25;0:87–96. doi: 10.1016/j.coi.2014.10.004

Figure 3.

Figure 3

Interactive model for the pathogenesis of SLE. This model makes the assumption that environmental triggers act on susceptible hosts. The triggers act on both genes controlling immune responsiveness and genes for end organ damage. These are two independent yet interactive pathways. Pathway I leads to the generation of autoantibodies and autoreactive effector T cells. Pathway II provides autoantigens and/or soluble mediators that influence immune responsiveness. Pathways I and II interact at several levels as indicated by III. These interactions can lead to end organ damage.