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. 2015 Jan;22(1):39–46. doi: 10.1101/lm.036517.114

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© 2014 Kwapis et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — APV infusion into the prelimbic cortex before extinction disrupts extinction retention the following day for Trace, but not Delay animals. (A) Freezing during training for Delay (top) and Trace (bottom) animals. Data are shown as average percent time freezing per minute. (B) Freezing during the first eight CS presentations of the extinction session. APV infusion before extinction did not impair freezing for either Delay or Trace animals. (C) Freezing during the extinction retention test on day 3. Trace animals given APV show impaired extinction retention relative to ACSF controls. APV did not affect extinction for Delay animals. (*) P < 0.05.