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. 2015 Jan;22(1):39–46. doi: 10.1101/lm.036517.114

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© 2014 Kwapis et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — APV infusion into the infralimbic cortex impairs freezing during extinction and enhances extinction retention the following day for both Delay and Trace animals. (A) Freezing during training for Delay (top) and Trace (bottom) animals. Data are shown as average percent time freezing per minute. (B) Freezing during the first eight CS presentations of the extinction session. APV infusion before extinction impaired freezing for both Delay and Trace animals. (C) Freezing during the extinction retention test on day 3. Both Delay and Trace animals infused with APV show enhanced extinction retention relative to ACSF controls. (*) P < 0.05.