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. 2004 Jul;72(7):3716–3723. doi: 10.1128/IAI.72.7.3716-3723.2004

FIG. 2.

FIG. 2.

P.69 Prn epitopes recognized by MAbs and human sera. (A) The numbers of MAbs binding to a particular peptide and the percentages of human sera that contain antibodies binding to a particular peptide are indicated on the right and left y axes, respectively. The numbers on the x axis refer to the P.69 Prn amino acid residues. Numbering starts with the N terminus of the processed protein. Epitopes recognized by <36% of the human sera are not shown. Epitopes are numbered to facilitate identification. (B) A minimal sequence with the corresponding amino acid residues of the epitopes. (C) Visualization of epitopes recognized by human and mouse antibodies. Epitopes are numbered to facilitate identification. Numbering starts with the N terminus of the processed protein. Epitopes recognized by <36% of the human sera are not shown. The crystal structure does not include the last 138 C-terminal amino acids of P.69 Prn, which harbor region 2. Successive epitopes are colored red and yellow to facilitate discrimination.