Table 3. Effects of baseline adenoma attributes on the odds of adenoma recurrence, development of an advanced adenoma, or incident invasive colorectal adenocarcinomaa.
| Predictor | Grouped as |
Most advanced lesion in follow-up
Odds ratio (95% CI low, high;
P
value) |
||
|---|---|---|---|---|
| Any adenoma N=537/3,300 | Advanced adenoma N=354/3,300 | ICRC N=14/3,300 | ||
| Number of adenomas | ≥3 vs. 1 or 2 | 1.8 (1.5, 2.2; <0.0001) | 2.4 (1.9, 3.0; <0.0001) | 4.3 (1.4, 12.9; 0.01) |
| Size | ≥10 mm vs. 1–9 | 3.1 (2.5, 3.8; <0.0001) | 3.6 (2.8, 4.5; <0.0001) | 5.2 (1.8, 15.1; 0.03) |
| High-grade dysplasia | Present vs. absent | 3.9 (2.1, 7.4; <0.0001) | 4.3 (2.2, 8.4; <0.0001) | 13.2 (2.8, 62.1; 0.001) |
| Villous morphology | Present vs. absent | 2.7 (2.2, 3.4; <0.0001) | 3.7 (2.9, 4.7; <0.0001) | 7.4 (2.5, 21.5; 0.01) |
Abbreviations: ICRC, incident invasive colorectal adenocarcinoma.
Advanced adenoma: adenoma with ≥1 risk attributes. Risk attributes were defined at namely the number (≥3) and size (≥10 mm) of adenomas, and the presence of high-grade dysplasia or villous morphology; any adenoma: any adenoma (including tubular, sessile, or flat) with or without risk attributes; ICRC, incident invasive colorectal adenocarcinoma.
a
Analysis adjusted for age, sex, smoking status, and family history of CRC.