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. 2014 Nov 4;143(1):209–219. doi: 10.1093/toxsci/kfu222

FIG. 3.

FIG. 3.

Ro4-1284 pretreatment attenuates horizontal velocity and vertical activity in MDMA-treated rats. Locomotor activity was monitored by placing animals into open-field activity chambers. Baseline levels of locomotor activity were measured for 30 min, followed by a 60-min pretreatment period with either DMSO or Ro4-1284 (10 mg/kg, ip) and a 120-min post-treatment period after MDMA (20 mg/kg, sc) or saline administration. Graphs show the mean (SE ± 6–7) horizontal (A) and vertical (B) activity at each time interval. The black arrow represents the time of Ro4-1284 pretreatment and zero indicates the time of MDMA dosing. Scatter plots display total horizontal and vertical locomotion over the entire testing period for each treatment group. Values are different from the saline group at (*) P < 0.05, from the Ro4-1284/saline group at (#) P < 0.05 and from the MDMA group at (ξ) P < 0.05.