Skip to main content
. 2014 Nov 4;143(1):209–219. doi: 10.1093/toxsci/kfu222

FIG. 4.

FIG. 4.

Ro4-1284 pretreatment affords protection against long-lasting MDMA-induced tissue 5-HT depletions. 5-HT and 5-HIAA levels were measured from cortex (A, C) and striatum (B, D) 7 days after MDMA exposure by HPLC-CEAS. Ro4-1284 (10 mg/kg, ip) was administered 1 h prior to MDMA treatment (20 mg/kg, sc). Results show individual concentrations of tissue indoleamines for each treatment group. Values are different from the saline group at (*) P < 0.05, from the Ro4-1284/saline group at (#) P < 0.05 and from the MDMA group at (ξ) P < 0.05.