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Model of the regulation of PIA synthesis in S. epidermidis. Transcription of icaADBC is regulated by the activity of the negative regulator IcaR (14). Transcription of icaR is negatively regulated by ethanol (15) and independently by a σB-dependent negative regulator, which is yet unknown. Additionally, PIA synthesis is regulated posttranscriptionally by a yet-unknown glucose-dependent regulator (17).
