Table 1. Spearman's correlation between gut microbiota composition represented by the first three coordinates of weighted UniFrac PCoA and host MS parameters.
| MS parameters |
PCoA1 |
PCoA2 |
PCoA3 |
|||
|---|---|---|---|---|---|---|
| r | P | r | P | r | P | |
| Serum adiponectin/body weight | 0.52 | 0.001 | 0.22 | 0.174 | −0.05 | 0.784 |
| eAT adiponectin mRNA | 0.27 | 0.099 | −0.05 | 0.753 | −0.02 | 0.916 |
| Weight gain | −0.57 | <0.001 | −0.36 | 0.023 | 0.02 | 0.917 |
| AUC of OGTT | −0.64 | <0.001 | −0.22 | 0.181 | −0.09 | 0.593 |
| FBG | −0.40 | 0.012 | −0.48 | 0.002 | 0.06 | 0.704 |
| FINS | −0.41 | 0.009 | −0.25 | 0.126 | 0.07 | 0.689 |
| HOMA-IR | −0.43 | 0.006 | −0.32 | 0.044 | 0.05 | 0.752 |
| Serum LBP | −0.42 | 0.008 | −0.04 | 0.806 | 0.35 | 0.028 |
| Adipocyte size | −0.62 | <0.001 | −0.21 | 0.198 | 0.11 | 0.502 |
| eAT CLS | −0.64 | 0.001 | −0.10 | 0.635 | −0.01 | 0.963 |
| eAT CD11c mRNA | −0.57 | <0.001 | −0.14 | 0.403 | −0.09 | 0.567 |
| eAT MMP-12 | −0.47 | 0.002 | −0.42 | 0.007 | 0.02 | 0.904 |
| eAT TNF-α mRNA | −0.39 | 0.014 | −0.23 | 0.156 | −0.04 | 0.819 |
| eAT MCP-1 mRNA | −0.41 | 0.010 | −0.35 | 0.028 | 0.18 | 0.266 |
| Liver TNF-α mRNA | −0.23 | 0.151 | −0.47 | 0.003 | −0.25 | 0.132 |
| Jejunum TNF-α mRNA | −0.33 | 0.043 | −0.26 | 0.107 | −0.04 | 0.796 |
Abbreviations: AUC, area under the curve; CLS, crown-like structures; eAT, epididymal adipose tissue; FBG, fasting blood glucose; FINS, fasting insulin; HOMA-IR, homeostasis model assessment of insulin resistance; LBP, lipopolysaccharide-binding protein; MCP-1, monocyte chemotactic protein 1; MMP-12, matrix metalloproteinase-12; MS, metabolic syndrome; OGTT, oral glucose tolerance tests; PCoA, principal coordinate analysis; TNF-α, tumor necrosis factor-α.
PCoA1–PCoA3 represents the first three principal components of weighted UniFrac PCoA of the gut microbita across all the animal groups at twelfth week of the trial. Significant correlations (P<0.05) are in bold.