Table. Summary of known characteristics of chitotriosidase.
| Other names (Aliases) | Chitinase 1 (CHIT1); CHI3; CHITD |
|---|---|
| Site of expression (tissues and cells) | Mature monocytes derived macrophages; lung macrophages |
| Gaucher cells | |
| Neutrophils | |
| Lung alveolar epithelial cells | |
| Intestinal epithelial cells | |
| Biological activity | Chitolytic enzyme activity: hydrolytic and trans-glycosylation activity |
| Disease association | Infectious diseases |
| - Fungal | |
| - Bacterial | |
| - Malaria | |
| Lysosomal storage diseases | |
| - Gaucher disease | |
| - Niemann Pick disease | |
| - Fabry disease | |
| β-thalassemia | |
| Atherosclerosis | |
| Lung diseases | |
| - Tuberculosis | |
| - Sarcoidosis | |
| - Idiopathic pulmonary fibrosis | |
| - Scleroderma associated interstitial lung disease | |
| - Asthma/atopy associated with fungal infection | |
| Liver disease | |
| - Non-alcoholic steatohepatitis (NASH) | |
| Neurodegenerative diseases | |
| - Alzheimer's disease | |
| - Ischemic cerebrovascular dementia |