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Dissemination of L. monocytogenes from the gastrointestinal tract to the spleen and liver is greater in P-glycoprotein knockout (mdr1a−/−) mice than wild-type mice after oral inoculation (five per group per study day). Mice were given 107 L. monocytogenes organisms in the stomach, and dissemination was measured on days 1 and 3 postinoculation. Data are means plus SD. *, P < 0.05.
