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. 2014 Dec 23;4:7588. doi: 10.1038/srep07588

Table 2. Selected characteristic amino acids of the novel influenza A(H2N2) virus.

Viral protein Amino acid position A/duck/WX/2/13 Comments
PB2 627 E E627K: Mammalian host adaptation42,43
HA 138 A S138A: Increased virus binding to human-type receptors44
  186 N G186V: Increased virus binding to human-type receptors45
  190 E E190D: Increased virus binding to human-type receptors46
  225 G G225D: Increased virus binding to human-type receptors46
  226 Q Q226L: Increased virus binding to human-type receptors26
  228 G H2N2 Human: S47
NA 65-71 No deletion Deletion of 65–71 increased virulence in mice48
M1 30 D N30D: Increased virulence in mice (most influenza A viruses encode 30D)49
  174 R K174K(R): Host marker of influenza A44
NS1 42 S P42S: Increased virulence in mice (most avian influenza A viruses encode 42S)50
  97 E D97E: Increased avian H5N1 viruses' virulence in mammals47
  127 N TDRVA127N: Association with H3N2 virulence47

HA amino acid residues have H3 numbering; NA amino acid residues have N2 numbering.