Table 2. Selected characteristic amino acids of the novel influenza A(H2N2) virus.
Viral protein | Amino acid position | A/duck/WX/2/13 | Comments |
---|---|---|---|
PB2 | 627 | E | E627K: Mammalian host adaptation42,43 |
HA | 138 | A | S138A: Increased virus binding to human-type receptors44 |
186 | N | G186V: Increased virus binding to human-type receptors45 | |
190 | E | E190D: Increased virus binding to human-type receptors46 | |
225 | G | G225D: Increased virus binding to human-type receptors46 | |
226 | Q | Q226L: Increased virus binding to human-type receptors26 | |
228 | G | H2N2 Human: S47 | |
NA | 65-71 | No deletion | Deletion of 65–71 increased virulence in mice48 |
M1 | 30 | D | N30D: Increased virulence in mice (most influenza A viruses encode 30D)49 |
174 | R | K174K(R): Host marker of influenza A44 | |
NS1 | 42 | S | P42S: Increased virulence in mice (most avian influenza A viruses encode 42S)50 |
97 | E | D97E: Increased avian H5N1 viruses' virulence in mammals47 | |
127 | N | TDRVA127N: Association with H3N2 virulence47 |
HA amino acid residues have H3 numbering; NA amino acid residues have N2 numbering.