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. 2014 Dec 23;4:7601. doi: 10.1038/srep07601

Figure 5. Polysaccharides reduced microglia activation in rd10/Cx3cr1+/GFP mouse retinas.

Figure 5

(a–c). Microglia have a ramified morphology in WT retinas ((a), arrowheads), while microglia show an ameboid shape in rd10 retinas at P26 ((b), arrows). After polysaccharides treatment, microglia maintained a ramified morphology in rd10 retinas ((c), arrowheads). (d–f). CD68 staining is undetectable in WT retinas ((d), arrowheads), and CD68 staining is intense and widespread in rd10 retinas ((e), arrows). However, CD68 staining is reduced in polysaccharides-treated rd10 retinas ((f), arrowheads). (g–i). Merged images. (j). Western blot of CD68 protein expression in the retina of WT, polysaccharides- and PBS-treated rd10 mice. (k–l). Analysis of TNF-α (k) and IL-6β (l) expressions in the retina of WT and polysaccharides- and PBS-treated rd10 mice by ELISA. N, number of retinas in each group. Results are presented as means ± SDs, ns, not significant, **: p < 0.01.

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