TABLE 7.

Organ infection in mice immunized orally with different doses of strain WR201 bacteria and challenged i.n. 8 weeks later with strain 16M bacteria^a

Inoculum	Result for:
	Spleen		Lung		Liver
	No. infected/total no.	Mean log (CFU ± SD)	No. infected/total no.	Mean log (CFU ± SD)	No. infected/total no.	Mean log (CFU ± SD)
Saline	17/17	3.84 ± 0.95	12/14	1.59 ± 0.96	10/12	1.39 ± 0.94
WR201 (CFU)
109	16/17	3.17 ± 1.50	11/15	1.41 ± 0.92	9/17	0.90 ± 1.08
1010	10/17b	1.63 ± 1.68c	11/17	1.10 ± 1.00	6/17b	0.48 ± 0.81d
1011	9/17b	1.38 ± 1.53c	9/14	1.32 ± 1.22	5/16b	0.54 ± 0.92e

^aAnimals were immunized with the indicated number of CFU of WR201, challenged i.n. with 10⁴ 16M, and euthanized 8 weeks after challenge. The number of bacterial CFU in organs was determined by serial dilution and plating of tissue homogenates.

^bSignificantly different from sham-immunized (saline) group by Fisher's exact test.

^cSignificantly different from sham-immunized (saline) group and from 10⁹ CFU group by ANOVA with Tukey's simultaneous pairwise comparisons.

^dP = 0.064 versus saline group by ANOVA with Tukey's simultaneous pairwise comparisons.

^eP = 0.096 versus saline group by ANOVA with Tukey's simultaneous pairwise comparisons.