Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan;21(1):61–74. doi: 10.1261/rna.047639.114

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Guy and Phizicky; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

FIGURE 1. — Trm7 modification machinery in eukaryotes. (A) Schematic of the anticodon loop of tRNA^Phe and tRNA^Leu(UAA) from S. cerevisiae. S. cerevisiae Trm7 (Sc Trm7) requires Sc Trm732 and Sc Trm734 to form Cm₃₂, and Nm₃₄, respectively, on tRNA^Phe and tRNA^Leu(UAA). Cm₃₂ and Gm₃₄ modification then drive yW formation from m¹G on tRNA^Phe. Wider arrow for Gm₃₄ indicates that yW formation is more dependent on this modification than on Cm₃₂. Predicted human homologs of Sc Trm7, Sc Trm732, and Sc Trm734 are in brackets. (B) Amino acid sequence alignment of Sc Trm7 with putative homologs from S. pombe and H. sapiens. (C) Schematic representation of Sc Trm732 aligned with putative homologs from S. pombe and H. sapiens. Inset box is an amino acid alignment of the DUF2428 domain found in these proteins.