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. Author manuscript; available in PMC: 2014 Dec 23.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2012 Jan 13;5(1):163–172. doi: 10.1161/CIRCEP.111.967604

Figure 3.

Figure 3

Whole-cell and single channel properties of Cx40-WT and Cx40-Q58L channels. A: Voltage pulse (top) and junctional current (bottom) from a homomeric WT cell pair (left; Gj=12.9 nS) and a Q58L cell pair (right; Gj=1.2 nS). B: Unitary currents recorded from homomeric Cx40-WT (upper) and Cx40-Q58L (lower) channels. O1 and O2 refer to two conducting (open) unitary levels of current. C: All-event histograms pooled from WT (left; N=3) and Q58L (right; N=3) cells with homologous channels. WT: Gaussian peaks centered at 136.2±2.3 pS and 53.1±5.3 pS. Q58L: Best fit by a single Gaussian distribution centered at 40.2±0.3 pS (N=3). D: Frequency of events in relation to dwell open time. Binned data were fit by single exponentials. τopen: WT=27.9±0.5 msec, N=4 cells, n=186 events; Q58L= 92.0±7.8 msec, N=3 cells, n=163 events).