Table 3.
Comparison of clinical characteristics of patients in whom factor XIII concentrate was effective for persistent air leak and those in whom it was ineffective
| Variables | EF | inEF | P value |
|---|---|---|---|
| Sex (Male/Female) | 21/5 | 9/2 | 0.941 |
| Age | 68 (61–72) | 72 (69–77) | 0.018 |
| BMI | 21.4 (19.9–24.9) | 18.7 (18.0–19.4) | <0.001 |
| Smoking Index | 950 (600–1783) | 940 (600–1400) | |
| Ever-smoker/Never | 22/4 | 10/1 | 0.609 |
| Diabetes (Yes/No) | 6/20 | 3/8 | 0.786 |
| FEV1.0% | 71.1 (59.6–77.2) | 70.0 (64.9–83) | 0.561 |
| DLCO% | 84.4 (72.4–104.1) | 82.3 (68.6–99.9) | 0.698 |
| COPD/IP (Yes/ No) | 15/11 | 9/2 | 0.160 |
| Operative procedure (upper or bilobectomy/other) | 17/9 | 6/5 | 0.534 |
| Pleural Adhesion (major/minor or no) | 6/20 | 1/10 | 0.321 |
| Repair air leak during operation | |||
| No | 3 | 0 | 0.137 |
| PGA sheet or suture | 3 | 4 | |
| Both PGA and suture | 20 | 7 | |
| Fibrin glue during operation (Yes/No) | 25/1 | 10/1 | 0.519 |
| Air leak at first postoperative day | |||
| Forced expiratory only | 8 | 5 | 0.276 |
| Expiratory only | 12 | 2 | |
| Continuous | 6 | 4 | |
| Duration of air leak (days) | 7 (6–9) | 15 (10–19) | <0.001 |
| Duration of drainage (days) | 8 (7–11) | 17 (15–22) | <0.001 |
| Drainage amount of 5 days (ml) | 1220 (1050–1543) | 1054 (626–1554) | 0.291 |
| Plasma factor XIII activity (%) | |||
| Before operation | 110 (89–130) | 123 (99–147) | 0.394 |
| Postoperative day 5 | 74 (64–86) | 91 (77–125) | 0.030 |
| Decrease ratio (%) | 24 (7–39) | 14 (1–36) | 0.393 |
Results are expressed as median and interquartile range.
Abbreviations: EF group of patients in whom the air leak resolved during FXIII administration, inEF group of patients who required additional intervention despite FXIII, BMI body mass index, COPD chronic obstructive pulmonary disease, DLCO carbon monoxide diffusing capacity, FEV1.0% forced expiratory volume in 1 s (predicted), IP interstitial pneumonia, PGA polyglycolic acid.