Table 3.
Simulation of ΔI and ΔE rev methods to estimate q in conditions similar to rat proximal tubule in the absence or presence of a Na + /D-glucose cotransporter
| [HCO 3 − ] o = 24, [HCO 3 − ] i = 13.4 | V I=0 (mV) | ΔE rev (mV) | q (ΔE rev ) | ΔI 2 /ΔI 1 V 2 -V 1 = 10 mV | q (ΔI) | |
|---|---|---|---|---|---|---|
| [Na + ] i = 17 mM | [Na + ] o = 150 | [Na + ] o = 100 | ||||
| q = 2 | −89.6 | −78.75 | 10.85 | 2.0 | 1.205 | 2.0 |
| q = 3 | −52.6 | −47.2 | 5.4 | 3.0 | 1.45 | 3.0 |
| q = 2, + Glu | −73.6 | −62.75 | 10.85 | 2.0 | 1.205 | 2.0 |
| q = 3, + Glu | 3.2 | 10.2 | 7.0 | 2.55 | 1.45 | 3.0 |
Glu represent a Na+/D-glucose cotransporter SGLT2 in the conditions of glucose concentrations [G]o = 5, [G]i = 1 and [Na+]o = 150, [Na+]i = 17 (in mM). Column q (ΔErev) represent q values estimated with ΔErev method. Column q (ΔI) represent q values estimated with ΔI method.