Table 3.
Frequency of promoter hypermethylation in patients with recurrent or non recurrent disease
| Gene ID |
% R |
% NR |
Overall series |
P |
|---|---|---|---|---|
| (Total = 31) | (Total = 47) | (Total = 78) | ||
|
FHIT
|
38.71 (12/31) |
2.13 (1/47) |
16.67 (13/78) |
3.1E-05 |
|
MLH1
|
25.81 (8/31) |
2.13 (1/47) |
11.54 (9/78) |
0.002 |
|
ATM
|
22.58 (7/31) |
2.13 (1/47) |
10.26 (8/78) |
0.006 |
|
TP73
|
35.48 (11/31) |
12.77 (6/47) |
21.79 (17/78) |
0.025 |
|
BRCA1
|
9.68 (3/31) |
0.00 (0/47) |
3.85 (3/78) |
0.059 |
|
CHFR
|
29.03 (9/31) |
10.64 (5/47) |
17.95 (14/78) |
0.068 |
|
IGSF4
|
12.90 (4/31) |
2.13 (1/47) |
6.41 (5/78) |
0.078 |
|
ESR1
|
70.97 (22/31) |
85.11 (40/47) |
79.49 (62/78) |
0.158 |
|
DAPK1
|
22.58 (7/31) |
10.64 (5/47) |
15.38 (12/78) |
0.203 |
|
CDKN2B
|
45.16 (14/31) |
29.79 (14/47) |
35.90 (28/78) |
0.228 |
|
RASSF1
CpG1 |
41.94 (13/31) |
29.79 (14/47) |
34.62 (27/78) |
0.333 |
|
RASSF1
CpG2 |
12.90 (4/31) |
6.38 (3/47) |
8.97 (7/78) |
0.427 |
|
HIC1
|
16.13 (5/31) |
8.51 (4/47) |
11.54 (9/78) |
0.471 |
|
CDKN2A
|
22.58 (7/31) |
14.89 (7/47) |
17.95 (14/78) |
0.548 |
|
CASP8
|
6.45 (2/31) |
2.13 (1/47) |
3.85 (3/78) |
0.560 |
|
CDH13
|
80.65 (25/31) |
74.47 (35/47) |
76.92 (60/78) |
0.592 |
|
CD44
|
3.23 (1/31) |
8.51 (4/47) |
6.41 (5/78) |
0.643 |
|
BRCA2
|
12.90 (4/31) |
8.51 (4/47) |
10.26 (8/78) |
0.706 |
|
RARB
|
48.39 (15/31) |
44.68 (21/47) |
46.15 (36/78) |
0.818 |
|
APC
|
45.16 (14/31) |
48.94 (23/47) |
47.44 (37/78) |
0.819 |
|
TIMP3
|
38.71 (12/31) |
36.17 (17/47) |
37.18 (29/78) |
1.000 |
|
CDKN1B
|
9.68 (3/31) |
8.51 (4/47) |
8.97 (7/78) |
1.000 |
|
VHL
|
6.45 (2/31) |
6.38 (3/47) |
6.41 (5/78) |
1.000 |
| PTEN | 3.23 (1/31) | 4.26 (2/47) | 3.85 (3/78) | 1.000 |
Abbreviations: R recurrent disease, NR non recurrent disease. P-value < 0.05.